Hortobagyi breast cancer

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We randomly assigned the patients to receive either ribociclib mg per day on a 3-weeks-on, 1-week-off schedule plus letrozole 2. The Hortobagyi breast cancer end point was investigator-assessed progression-free survival. Secondary end points included overall survival, overall response rate, and safety. A preplanned interim analysis was Hortobagyi breast cancer on January 29,after patients had disease Hortobagyi breast cancer or died. Prespecified criteria for superiority required a hazard ratio of 0. The duration of progression-free survival was significantly longer in the ribociclib group than in the placebo group hazard ratio, 0. The median duration of follow-up was After 18 months, the progression-free survival rate was In patients with measurable disease at baseline, the overall response rate was Among patients receiving initial systemic treatment for HR-positive, HER2-negative advanced breast cancer, the duration of progression-free survival was significantly longer among those receiving ribociclib plus letrozole than among Hortobagyi breast cancer receiving placebo plus letrozole, with a higher rate of myelosuppression in the ribociclib group. Funded by Novartis Pharmaceuticals; ClinicalTrials. National Center for Biotechnology InformationU. Didn't get the message? Add to My Bibliography. Generate a file for use with external citation management software. N Engl J Hortobagyi breast cancer. Epub Oct 7. Author information 1 From the University of Texas M. Anderson Cancer Center, Houston Petite modern women clothing. Sammons Cancer Center and the U. Oncology Network, Dallas J. Supplemental Content Full text links. Please review our privacy policy.

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Hortobagyi breast cancer

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Gabriel N. Hortobagyi, MD, is a professor of medicine in the Department of Breast Medical Oncology and the Nellie B. Connally Chair in Breast Cancer at The. Nov 9, - Gabriel N. Hortobagyi, MD, professor of Medicine at the University of Texas MD with hormone receptor (HR)-positive advanced breast cancer. Director, Department of Breast Medical Oncology The University of Texas MD Anderson Cancer CenterHortobagyi developed, implemented and chaired a.

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